SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| text
| recycling endosomes and LEL (Cheng 2010) |
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is present in lysosomes, late endosomes, recycling endosomes and, at a lower level, the plasma membrane  |
| basic FUNCTION
| with MCOLN1, dictate the localization of MCOLN3 and not vice versa (Venkatachalam 2006) |
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traffics via the Arf6-associated pathway and colocalizes with major histocompatibility protein class I (MHCI) and glycosylphosphatidylinositol-anchored proteins (GPI-APs), such as CD59 in both vesicles and long tubular structures (Karacsonyi 2007) |
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may have a role in the traffic of cargo through the Arf6-associated pathway (Karacsonyi 2007) |
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with MCOLN3, might participate with native MCOLN1 in a dynamic form of lysosomal regulation (Zeevi 2009) |
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displays nonselective cation permeability |
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induces cell degeneration by Ca2+ overload |
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may function in the plasma membrane and its abundance in vesicles of the endocytic pathaway might occur because its presence in the cell surface is regulated by endocytosis and exocytosis |
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MCOLN2 and MCOLN3 are nonselective cation channels |
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functional activity of MCOLN2 at the plasma membrane and suggesting similar gating mechanisms for both TRPML channels |
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serves a role in the immune system, and its expression would be likely regulated by an immune-associated transcription factor protein |
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may serve a critical role in immune cell development and inflammatory responses |
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novel role for TRPML2 in the innate immune response (pMID: 26432893) |
