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FLASH GENE

Symbol

EEF1A2

contributors: mct - updated : 15-10-2015

HGNC name	eukaryotic translation elongation factor 1 alpha 2
HGNC id	3192

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001958 8 - 1841 NP_001949 - 463 not in skeletal - variant 2 8 - 1848 isoform 2 50 463 only heart, brain, aorta, skeletal muscle 1996 8812466

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies

homolog to murine Eef1a2

intraspecies

paralog to highly similar (98p100) to the near-ubiquitously expressed EEF1A1

Homologene

FAMILY	GTP-binding elongation factor family
	EF-Tu/EF-1A subfamily

CATEGORY

regulatory , RNA associated , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	promoting the transfer of aminoacylated tRNA to the A site of the ribosome
	oncogenicity of eEF1A2 may be related either to its role in protein synthesis or to potential non-canonical functions
	regulates oncogenesis through AKT1 and PI3K-dependent cytoskeletal remodeling
	might play an important role in pancreatic carcinogenesis, possibly by acting as a tumour oncogene
	important role for EEF1A2 in driving cap-independent translation of utrophin A in skeletal muscle
	PI4KB, EEF1A2 and PI(4)P likely play an important role in mammary neoplasia and acinar development
	is involved in protein synthesis, suppression of apoptosis, and regulation of actin function and cytoskeletal structure
	plays an important role in prostate cancer development, especially in inhibiting apoptosis
	both EEF1A1 and EEF1A2 colocalise with all EEF1B2 subunits, in such close proximity that they are highly likely to be in a complex
	stimulates the phospholipid signaling and activates the AKT1 -dependent cell migration and actin remodeling that ultimately favors tumorigenesis
	EEF1A1, and EEF1A2 proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis, and increased viral pathogenesis

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	translation requires the specific attachment of AAs to AARS and the subsequent delivery of aminoacyl-tRNAs to the ribosome by elongation factor 1 alpha (EEF1A2)
	interaction between LRRK2 and EEF1A1 and EEF1A2 may reciprocally modulate their physiological function
	interactions between EEF1A2 and ZPR1 (zinc-finger protein 1), which interacts with the SMN (survival motor neuron) protein, may be important in motor neuron biology
	EEF1A2 as a novel interacting partner CDKN2A, and interaction of CDKN2A with EEF1A2, and subsequent downregulation of the expression and function of EEF1A2 is a novel mechanism explaining the anti-proliferative effects of CDKN2A
	interaction with TSPY1, through six lysine residues observed in EEF1A2 suggesting their possible role in TSPY1-EEF1A2 complex formation essential for germ cell development and spermatogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRD38 , EIEE33

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian cancer tumoral   amplification     in lung adenocarcinoma tumoral     --over   in 83 p100 of pancreatic cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	EEF1A2 is potentially a diagnostic marker in various cancers
Therapy target
	System Type Disorder Pubmed cancer lung   potential targets for diagnosis and therapy in lung adenocarcinoma cancer reproductive prostate might serve as a potential therapeutic target in prostate cancer

ANIMAL & CELL MODELS

mice homozygous for the wasted mutation (deletion of Eef1A2) die of muscle wasting and neurodegeneration at four weeks post-natal