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FLASH GENE

Symbol

CCR4

contributors: mct - updated : 04-02-2015

HGNC name	chemokine (C-C motif) receptor 4
HGNC id	1605

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p22.3      Physical location : 32.993.065 - 32.996.403
Synonym name	small inducible cytokine, high affinity specific receptor for SCYA17 (TARC), expressed TC in skin but not in intestine
Synonym symbol(s)	CMKBR4, CC-CKR-4, K5-5, CKR4

DNA

TYPE	functioning gene
STRUCTURE	3.34 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005508 2 - 1657 - 360 - 1999 10466728

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective adipose     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic platelet Lymphoid/Immune lymphocyte Homo sapiens Skin/Tegument keratinocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Cmkbr4

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	preferentially expressed on Th2 lymphocytes

basic FUNCTION	specific receptor for thymus and activation-regulated chemokine
	plays an important role in T reg cell trafficking in lymph nodes and this is critical for T reg cell suppressive function
	CCR4 and CCR10 are expressed on epidermal keratinocytes and both are functional in terms of skin cytokine production and/or migration to their ligand CCL17 and CCL27, respectively
	associated with trafficking of specialized cutaneous memory type 2 T(h) cells in the skin
	involvement of CCR4 in inflammatory macrophage effector function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ligand CCL17 (CCR4/CCL17)
	CKLF with its C-terminal peptides can interact with CCR4

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in skin and lymph nodes of adult T-cell leukemia tumoral     --other   aberrant expression of CCR4 in gastric cancer could contribute to tumor-induced immunosuppression constitutional     --over   in Parkinson disease (PD)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach downmodulation of CCR4 expression could be a promising immunotherapy for human gastric cancer allergy     blocking CCR4-ligand interaction may provide a novel therapeutic approach in allergic disease

ANIMAL & CELL MODELS