Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TIA1 | contributors: mct - updated : 30-09-2011 |
HGNC name | TIA1 cytotoxic granule-associated RNA binding protein |
HGNC id | 11802 |
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Location | 2p13.3 Physical location : 70.436.576 - 70.475.779 |
Synonym name | |
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Synonym symbol(s) | TIA-1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 36.00 kb 12 Exon(s) |
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10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Binding site |
motif | repetitive sequence other |
text structure | Au rich element (ARE) in 3'utr |
MAPPING | cloned | Y | linked | status | confirmed |
regionally located | in the PARK3 region |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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isoforms | Precursor | p40-TIA1, precursor of a 15 kDa (p15-TIA-1) protein |
HOMOLOGY |
interspecies | homolog to murine Tia1 |
homolog to rattus LOC312510 |
Homologene |
FAMILY |
CATEGORY | RNA associated |
SUBCELLULAR LOCALIZATION
| intracellular |
intracellular,cytoplasm,cytosolic,granule | |
intracellular,nucleus | |
text | also colocalizing with POLR in stress granules, initiated by the phosphorylayion of EIF2A |
basic FUNCTION | |
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CELLULAR PROCESS
| cell life, cell death/apoptosis |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA | |
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small molecule |
protein | |
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cell & other |
REGULATION |
Other | regulated by TARDBP (TARDBP contributes to both the assembly and maintenance of stress granules (SGs)in response to oxidative stress and differentially regulates key SGs components, including TIA1 and G3BP1) ![]() | |
rapid and severe hypoxia caused co-aggregation of TIAL1/TIA1 and these proteins suppressed HIF1A expression ![]() |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |