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FLASH GENE
Symbol UBE2L3 contributors: mct - updated : 02-10-2018
HGNC name ubiquitin-conjugating enzyme E2L 3
HGNC id 12488
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
  • to Crohn disease
  • to Hashimoto thyroiditis (HT)
  • to systemic lupus erythematosus (SLE)
  • Variant & Polymorphism SNP
  • rs2298428 in UBE2L3 significantly associated with Crohn disease
  • TCGGC haplotype is associated with an increased risk of HT in a Chinese Han population
  • variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBE2L3 expression
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS