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FLASH GENE

Symbol

UBE2L3

contributors: mct - updated : 02-10-2018

HGNC name	ubiquitin-conjugating enzyme E2L 3
HGNC id	12488

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Crohn disease to Hashimoto thyroiditis (HT) to systemic lupus erythematosus (SLE)

Variant & Polymorphism SNP	rs2298428 in UBE2L3 significantly associated with Crohn disease
	TCGGC haplotype is associated with an increased risk of HT in a Chinese Han population
	variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBE2L3 expression

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS