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FLASH GENE

Symbol

UBE2L3

contributors: mct - updated : 02-10-2018

HGNC name	ubiquitin-conjugating enzyme E2L 3
HGNC id	12488

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	74.59 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	no TATA or CAAT,binding sites for AP2, Sp1

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - UBE2L3 - D22S446 - D22S1014E - D22S1003E - qter
Authors	Moynihan (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003347 4 - 2907 - 154 - 1998 9693040 NM_001256356 3 - 2932 NP_001243285 - 122 - 1998 9693040 NM_001256355 4 - 3007 NP_001243284 - 212 - 1998 9693040

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Lymphoid/Immune thymus       highly Reproductive female system uterus cervix   highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation

HOMOLOGY

intraspecies

homolog to L-UBC (UBE2L1)

Homologene

FAMILY

ubiquitin-conjugating enzyme family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	ubiquitin dependent proteolytic, mediating the selective degradation of short-lived and abnormal proteins
	ubiquitin conjugating enzyme mediating c-fos degradation NFKB maturation, human papilloma virus TP53 and MYC degradation in vitro
	dynamic cell cycle-dependent changes in levels of UBE2L3 regulate entrance into and progression through S phase
	potential role for its targets in the completion of S phase and entry into G2
	promotes S phase progression to G2 by modulating the intra-S phase checkpoint mediated by CHEK1
	reported to function with members of the RING E3 family known as RBRs, which includes parkin and ARIH1
	exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes PARK2 and ARIH1
	regulates both the steady-state and replicative stress-induced ubiquitination and proteasome-dependent degradation of the tumor suppressor TP53-binding protein 1 (TP53BP1)
	important role for UBE2L3 in plasmablast and plasma cell development

CELLULAR PROCESS	cell cycle
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	UBOX5
	ARIH1 interacts and co-localizes with UBE2L3 in mammalian cells, particularly in the perinuclear region
	both UBE2L3 and UBE2L6 bind to RNF19B
	interaction between the E3 ubiquitin ligase ITCH and the E2 UBE2L3
	binding UBE3A
	UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
	MAP1B-LC1 (light chain) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway
	NDFIP1 acts as an adaptor for UBE2L3 and ITCH
	controls IL1B secretion by inflammasomes
	CASP1, controls pyroptosis- and ubiquitin-independent proteasomal degradation of UBE2L3 upon canonical and non-canonical inflammasome activation by sterile danger signals and bacterial infection
	specifically protects CDKN1B from degradation
	UBE2L3 catalyzes the conjugation of heterotypic ubiquitin chains on CDKN1B that are proteolytically incompetent

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Crohn disease to Hashimoto thyroiditis (HT) to systemic lupus erythematosus (SLE)

Variant & Polymorphism SNP	rs2298428 in UBE2L3 significantly associated with Crohn disease
	TCGGC haplotype is associated with an increased risk of HT in a Chinese Han population
	variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBE2L3 expression

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS