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FLASH GENE
Symbol UBE2L3 contributors: mct - updated : 02-10-2018
HGNC name ubiquitin-conjugating enzyme E2L 3
HGNC id 12488
Location 22q11.21      Physical location : 21.921.956 - 21.978.323
Synonym name
  • ubiquitin carrier protein
  • ubiquitin-protein ligase
    • Synonym symbol(s) UBCH7, E2-F1, L-UBC, UbcM4
    EC.number 6.3.2.19/2.3.2.23
    DNA
    TYPE functioning gene
    STRUCTURE 74.59 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure no TATA or CAAT,binding sites for AP2, Sp1
    MAPPING cloned Y linked N status confirmed
    Map cen - UBE2L3 - D22S446 - D22S1014E - D22S1003E - qter
    Authors Moynihan (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2907 - 154 - 1998 9693040
    3 - 2932 - 122 - 1998 9693040
    4 - 3007 - 212 - 1998 9693040
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved UBC domain of 150AA harboring the cysteine residue required for enzyme-ubiquitin thioester formation
    • HOMOLOGY
    intraspecies homolog to L-UBC (UBE2L1)
    Homologene
    FAMILY ubiquitin-conjugating enzyme family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • ubiquitin dependent proteolytic, mediating the selective degradation of short-lived and abnormal proteins
  • ubiquitin conjugating enzyme mediating c-fos degradation NFKB maturation, human papilloma virus TP53 and MYC degradation in vitro
  • dynamic cell cycle-dependent changes in levels of UBE2L3 regulate entrance into and progression through S phase
  • potential role for its targets in the completion of S phase and entry into G2
  • promotes S phase progression to G2 by modulating the intra-S phase checkpoint mediated by CHEK1
  • reported to function with members of the RING E3 family known as RBRs, which includes parkin and ARIH1
  • exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes PARK2 and ARIH1
  • regulates both the steady-state and replicative stress-induced ubiquitination and proteasome-dependent degradation of the tumor suppressor TP53-binding protein 1 (TP53BP1)
  • important role for UBE2L3 in plasmablast and plasma cell development
    • CELLULAR PROCESS cell cycle
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBOX5
  • ARIH1 interacts and co-localizes with UBE2L3 in mammalian cells, particularly in the perinuclear region
  • both UBE2L3 and UBE2L6 bind to RNF19B
  • interaction between the E3 ubiquitin ligase ITCH and the E2 UBE2L3
  • binding UBE3A
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
  • MAP1B-LC1 (light chain) could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway
  • NDFIP1 acts as an adaptor for UBE2L3 and ITCH
  • controls IL1B secretion by inflammasomes
  • CASP1, controls pyroptosis- and ubiquitin-independent proteasomal degradation of UBE2L3 upon canonical and non-canonical inflammasome activation by sterile danger signals and bacterial infection
  • specifically protects CDKN1B from degradation
  • UBE2L3 catalyzes the conjugation of heterotypic ubiquitin chains on CDKN1B that are proteolytically incompetent
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to Crohn disease
  • to Hashimoto thyroiditis (HT)
  • to systemic lupus erythematosus (SLE)
    • Variant & Polymorphism SNP
  • rs2298428 in UBE2L3 significantly associated with Crohn disease
  • TCGGC haplotype is associated with an increased risk of HT in a Chinese Han population
  • variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBE2L3 expression
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS