| Symbol
| WNT7A
| contributors: shn/npt/pgu - updated : 14-12-2018
|
| HGNC name
| wingless-type MMTV integration site family, member 7A
|
| HGNC id
| 12786
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
| |
in lung cancer in development or in progression (by its effect on E-cadherin) | | tumoral
|
|
| --over
|
| |
in pancreatic and gastric cancer | | tumoral
|
|
| --low
|
| |
in uterine leiomyoma inversely associated with the expression of estrogen receptor-alpha | | tumoral
|
|
| --over
|
|
in pancreatic cancer tissue compared with the adjacent non-tumor tissue and the expression of WNT7A positively correlates with poor prognosis and lymph node metastasis  | | tumoral
|
|
| --over
|
| |
in most colorectal cancer tissues but weakly expressed in adjacent normal mucosa, colorectal adenomas, and colonic polyps | | constitutional
|
|
|
| loss of function
| |
induces limbal stem or progenitor cells (LSCs) into skin-like epithelium, a critical defect tightly linked to common human corneal diseases | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| positive WNT7A, in addition to TNM stage, may be an independent prognosis factor influencingoverall survival (OS) and disease-free survival (DFS) prediction in Colorectal cancer patients | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| neuromuscular | myopathy | | |
| WNT7A is a potential treatment for muscle-wasting diseases |
| | |
|
| male mice lacking Wnt-7a fail to undergo regression of the Müllerian duct resulting of the absence of the receptor for Müllerian-inhibiting substance and Wnt7a-deficient females mice are infertile due to abnormal oviduct and uterus development | |
double-mutant mouse lacking both WNT7A and the downstream scaffold protein Dishevelled display defect in the release of neurotransmitter and localization of synaptic proteins is affected |
|
Wnt7a-Dvl1–deficient mice exhibit defects in spine morphogenesis and mossy fiber-CA3 synaptic transmission in the hippocampus |