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FLASH GENE
Symbol MCM6 contributors: npt/mct - updated : 07-04-2010
HGNC name minichromosome maintenance complex component 6
HGNC id 6949
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal phosphorylation site (phosphorylation play functionally redundant but essential roles in initiation of DNA replication)
  • CDT1 binding domain (CBD) (Wei 2010)
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm6 (minichromosome maintenance mutant)
    intraspecies homolog to cell division cycle
    Homologene
    FAMILY
  • MCM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • participating in the cell cycle control of genome duplication
  • playing an essential role for the initiation of eukaryotic genome replication
  • during S phase MCM6 functions as part of the replicative helicase but within the pre-replication, MCM6 is inactive
    • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • MCM8
  • specific MRC1-binding protein (binding of MRC1, a checkpoint mediator, to MCM6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress)(Komata 2009)
  • interaction between CDT1 and MCM6 appears to be essential for efficient loading of MCM6 onto template DNA (You 2008)
  • interacting with ARHGEF5 and TIPIN, both of which are involved in regulation of DNA replication fork progression (Numata 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in classic Hodgkin lymphoma (Karimi 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS