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FLASH GENE
Symbol MFSD10 contributors: mct/npt - updated : 14-11-2019
HGNC name major facilitator superfamily domain containing 10
HGNC id 16894
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve membrane-spanning domains
    • HOMOLOGY
    interspecies ortholog to Drosophila Tpo1p
    intraspecies homolog to Drosophila Drtet
    homolog to E. coli tetracycline transporter (TetA)
    Homologene
    FAMILY
  • major facilitator superfamily
  • tcr/tet family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nuclear envelope,int
    text
  • predominantly localized on cytoplasmic membranes
  • MFSD10, TMX4, and ARL6IP6 likely residing in the inner nuclear membrane
    • basic FUNCTION
  • having a tetracycline transporter activity
  • functioning as a metal-tetracycline/h(+) antiporter
  • efflux pump for non-steroidal anti-inflammatory drugs and the first major facilitator superfamily (MFS) protein identified that is involved in drug resistance in human cells
  • new type of membrane transporter involved in the transport of non-steroidal anti-inflammatory drugs
  • may be involved in the transport of organic anions across the luminal membranes of proximal tubules
  • eosinophil-specific cell surface molecule
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS