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FLASH GENE
Symbol MFSD10 contributors: mct/npt - updated : 14-11-2019
HGNC name major facilitator superfamily domain containing 10
HGNC id 16894
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Lymphoid/Immunetonsils   highly
Nervousnerve   highly
Reproductivefemale systemuteruscervix highly
 female systemovary  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve membrane-spanning domains
    • HOMOLOGY
    interspecies ortholog to Drosophila Tpo1p
    intraspecies homolog to Drosophila Drtet
    homolog to E. coli tetracycline transporter (TetA)
    Homologene
    FAMILY
  • major facilitator superfamily
  • tcr/tet family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nuclear envelope,int
    text
  • predominantly localized on cytoplasmic membranes
  • MFSD10, TMX4, and ARL6IP6 likely residing in the inner nuclear membrane
    • basic FUNCTION
  • having a tetracycline transporter activity
  • functioning as a metal-tetracycline/h(+) antiporter
  • efflux pump for non-steroidal anti-inflammatory drugs and the first major facilitator superfamily (MFS) protein identified that is involved in drug resistance in human cells
  • new type of membrane transporter involved in the transport of non-steroidal anti-inflammatory drugs
  • may be involved in the transport of organic anions across the luminal membranes of proximal tubules
  • eosinophil-specific cell surface molecule
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS