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FLASH GENE
Symbol PTH2R contributors: mct - updated : 21-01-2021
HGNC name parathyroid hormone 2 receptor
HGNC id 9609
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • G protein coupled receptor superfamily
  • parathyroid hormone (PTH) family of peptide hormones
    • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • coupling with Gs alpha protein and activating adenylate cyclase
  • may be functioning as a neurotransmitter receptor
  • involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception
  • PTH2-PTH2R system involved in nociceptive information processing in the spinal cord, in the regulation of different hypophysiotropic neurons in the hypothalamus, and in the modulation of affective behaviors
  • possible new central mechanism for endocannabinoid regulation, via PTH2 acting on the PTH2R in discrete brain regions
  • role for PTH2R signaling in postnatal growth plate development and subsequent bone mass acquisition
  • PTH2, via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory
  • novel role for PTH2R signaling in extracellular matrix production
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for parathyroid hormone (PTH)
  • PTH2/PTH2R signaling inhibits proliferation and alters differentiation of chondrocytes by modulating SOX9 expression, thereby substantiating the functional significance of this signaling pathway in chondrocyte biology
  • PTH2 acting via the PTH2R modulates several aspects of the stress response
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in hyperparathyroidism
    constitutional       loss of function
    in non-syndromic craniosynostosis (CRS) (NSC) patients
    Susceptibility to familial early-onset generalized osteoarthritis
    Variant & Polymorphism other polymorphism associated to familial early-onset generalized osteoarthritis (minor role)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS