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FLASH GENE
Symbol PTH2R contributors: mct - updated : 21-01-2021
HGNC name parathyroid hormone 2 receptor
HGNC id 9609
Location 2q33      Physical location : 209.271.555 - 209.359.224
Synonym name
  • parathyroid hormone receptor 2
  • PTH2 receptor
  • Synonym symbol(s) PTHR2
    DNA
    TYPE functioning gene
    STRUCTURE 134.81 kb     13 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2971 - 439 - 2015 26044810
    14 - 3038 - 439 - 2015 26044810
    14 - 3047 - 439 - 2015 26044810
    10 - 2695 - 347 - 2015 26044810
    13 - 2752 62 550 - 2015 26044810
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
     mouthtongue   
    Endocrinepancreas    
    Nervousbrain   predominantly Homo sapiens
     brainforebrain    Homo sapiens
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • parathyroid hormone (PTH) family of peptide hormones
  • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • coupling with Gs alpha protein and activating adenylate cyclase
  • may be functioning as a neurotransmitter receptor
  • involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception
  • PTH2-PTH2R system involved in nociceptive information processing in the spinal cord, in the regulation of different hypophysiotropic neurons in the hypothalamus, and in the modulation of affective behaviors
  • possible new central mechanism for endocannabinoid regulation, via PTH2 acting on the PTH2R in discrete brain regions
  • role for PTH2R signaling in postnatal growth plate development and subsequent bone mass acquisition
  • PTH2, via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory
  • novel role for PTH2R signaling in extracellular matrix production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for parathyroid hormone (PTH)
  • PTH2/PTH2R signaling inhibits proliferation and alters differentiation of chondrocytes by modulating SOX9 expression, thereby substantiating the functional significance of this signaling pathway in chondrocyte biology
  • PTH2 acting via the PTH2R modulates several aspects of the stress response
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in hyperparathyroidism
    constitutional       loss of function
    in non-syndromic craniosynostosis (CRS) (NSC) patients
    Susceptibility to familial early-onset generalized osteoarthritis
    Variant & Polymorphism other polymorphism associated to familial early-onset generalized osteoarthritis (minor role)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS