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FLASH GENE
Symbol TCF7L1 contributors: mct - updated : 19-04-2014
HGNC name transcription factor 7-like 1 (T-cell specific, HMG-box)
HGNC id 11640
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a HMG box
  • a beta-catenin binding domain
  • a nuclear localization signal
  • a gly-rich domain
  • a pro-rich domain
  • HOMOLOGY
    interspecies ortholog to murine Tcf3
    ortholog to rattus Tcf3_predicted
    intraspecies homolog to TCF7L2
    Homologene
    FAMILY TCF/LEF family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of transcription in a DNA-dependent manner
  • repressor activity in absence of CTNNB1
  • activator activity in its presence
  • down-regulates NQO1, resulting in a mytomycin C resistance
  • necessary for the terminal differenciation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis
  • unique requirement for TCF7L1 repressor function in restricting induction of the anterior-posterior axis
  • in the absence of Wnt signals, may function in skin stem cells to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage
  • important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development
  • cell-intrinsic inhibitor of pluripotent cell self-renewal that functions by limiting steady-state levels of self-renewal factors
  • transcriptional repressor that has been implicated in Wnt signaling and plays key roles in embryonic axis specification and stem cell differentiation
  • transcriptional hub coordinating cell–cell contact with the transcriptional repression required for adipogenic competency
  • represses structure-related genes during adipogenesis
  • adipogenic competency factor that uniquely determines adipogenic fate through cell structure organization required for adipocyte gene activation
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binds the armadillo repeat of CTNNB1 and forms a stable complex
  • TCF7L1-mediated control of NANOG levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
  • binds and directly regulates the expression of cell structure genes
  • indirectly regulates PPARG enhancer in early adipogenesis
  • TCF7L1-mediated cell structure changes contribute to PPARG2 induction, providing synchrony between adipogenic commitment and terminal differentiation
  • DGCR8 is a direct interactor of TCF7L1 mRNA, a core component of the pluripotency network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    occasionally, in primary gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tcf7l1 null mice are early embryonic lethal