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FLASH GENE

Symbol

TCF7L1

contributors: mct - updated : 19-04-2014

HGNC name	transcription factor 7-like 1 (T-cell specific, HMG-box)
HGNC id	11640

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031283 14 - 2932 NP_112573 - 588 - 2004 14668413

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue       Reproductive female system breast mammary gland

cells

System Cell Pubmed Species Stage Rna symbol Digestive epithelial cell Skin/Tegument hair follicle cell Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a HMG box
	a beta-catenin binding domain
	a nuclear localization signal
	a gly-rich domain
	a pro-rich domain

HOMOLOGY

interspecies	ortholog to murine Tcf3
	ortholog to rattus Tcf3_predicted

intraspecies

homolog to TCF7L2

Homologene

FAMILY

TCF/LEF family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in the regulation of transcription in a DNA-dependent manner
	repressor activity in absence of CTNNB1
	activator activity in its presence
	down-regulates NQO1, resulting in a mytomycin C resistance
	necessary for the terminal differenciation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis
	unique requirement for TCF7L1 repressor function in restricting induction of the anterior-posterior axis
	in the absence of Wnt signals, may function in skin stem cells to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage
	important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development
	cell-intrinsic inhibitor of pluripotent cell self-renewal that functions by limiting steady-state levels of self-renewal factors
	transcriptional repressor that has been implicated in Wnt signaling and plays key roles in embryonic axis specification and stem cell differentiation
	transcriptional hub coordinating cell–cell contact with the transcriptional repression required for adipogenic competency
	represses structure-related genes during adipogenesis
	adipogenic competency factor that uniquely determines adipogenic fate through cell structure organization required for adipocyte gene activation

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	binds the armadillo repeat of CTNNB1 and forms a stable complex
	TCF7L1-mediated control of NANOG levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
	binds and directly regulates the expression of cell structure genes
	indirectly regulates PPARG enhancer in early adipogenesis
	TCF7L1-mediated cell structure changes contribute to PPARG2 induction, providing synchrony between adipogenic commitment and terminal differentiation
	DGCR8 is a direct interactor of TCF7L1 mRNA, a core component of the pluripotency network

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   occasionally, in primary gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Tcf7l1 null mice are early embryonic lethal