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FLASH GENE
Symbol GNLY contributors: mct/npt - updated : 31-03-2009
HGNC name granulysin
HGNC id 4414
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY saposin-like protein (SAPLIP) family
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,granule
intracellular,nucleus
text
  • in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells
  • released into the granule via a calcium-dependent pathway into the intercellular space between effector and target cells (Chung 2008)
    • basic FUNCTION
  • involved in immunity against intracellular infection against M tuberculosis and other pathogens
  • having antimicrobial activity against M. tuberculosis and other organisms
  • exhibits cytolytic activity against a variety of intracellular microbes (Latinovic-Golic 2007)
  • cationic cytolytic protein released primarily by CTLs and NK cells, chemoattractant and proinflammatory activator, having a crucial role in cellular immunity (Chung 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulation in response to IL2 or bacterial antigen stimulation occurs at several levels: RNA expression, extensive alternative splicing and posttranslational processing (Latinovic-Golic 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the skin lesions of subjects with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis
    constitutional     --over  
    in peripheral blood cells of patients with primary biliary cirrhosis (Qian 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be used as a specific therapeutic target to develop a more effective therapy for Stevens-Johnson -toxic epidermal necrolysis
    ANIMAL & CELL MODELS