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FLASH GENE

Symbol

GNLY

contributors: mct/npt - updated : 31-03-2009

HGNC name	granulysin
HGNC id	4414

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Endocrine parathyroid       highly Lymphoid/Immune spleen       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic NK cell Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

saposin-like protein (SAPLIP) family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,nucleus
text	in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells
	released into the granule via a calcium-dependent pathway into the intercellular space between effector and target cells (Chung 2008)

basic FUNCTION	involved in immunity against intracellular infection against M tuberculosis and other pathogens
	having antimicrobial activity against M. tuberculosis and other organisms
	exhibits cytolytic activity against a variety of intracellular microbes (Latinovic-Golic 2007)
	cationic cytolytic protein released primarily by CTLs and NK cells, chemoattractant and proinflammatory activator, having a crucial role in cellular immunity (Chung 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulation in response to IL2 or bacterial antigen stimulation occurs at several levels: RNA expression, extensive alternative splicing and posttranslational processing (Latinovic-Golic 2007)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the skin lesions of subjects with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis constitutional     --over   in peripheral blood cells of patients with primary biliary cirrhosis (Qian 2008)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	could be used as a specific therapeutic target to develop a more effective therapy for Stevens-Johnson -toxic epidermal necrolysis

ANIMAL & CELL MODELS