secreted extracellularly by NK cells and cytotoxic lymphocytes via a nongranule exocytotic pathway, and its concentrations are elevated after T cell activatio (Chung 2008)
6
splicing
995
-
129
-
Jongstra, Deng, Chung (2008)
includes an additional 242 bp segment
-
-
-
9
-
-
Chung (2008)
released into the granule via a calcium-dependent pathway into the intercellular space between effector and target cells
in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells
released into the granule via a calcium-dependent pathway into the intercellular space between effector and target cells (Chung 2008)
basic FUNCTION
involved in immunity against intracellular infection against M tuberculosis and other pathogens
having antimicrobial activity against M. tuberculosis and other organisms
exhibits cytolytic activity against a variety of intracellular microbes (Latinovic-Golic 2007)
cationic cytolytic protein released primarily by CTLs and NK cells, chemoattractant and proinflammatory activator, having a crucial role in cellular immunity (Chung 2008)
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
Other
regulation in response to IL2 or bacterial antigen stimulation occurs at several levels: RNA expression, extensive alternative splicing and posttranslational processing (Latinovic-Golic 2007)
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
Type
Gene Modification
Chromosome rearrangement
Protein expression
Protein Function
constitutional
--over
in the skin lesions of subjects with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis
constitutional
--over
in peripheral blood cells of patients with primary biliary cirrhosis (Qian 2008)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
could be used as a specific therapeutic target to develop a more effective therapy for Stevens-Johnson -toxic epidermal necrolysis
