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FLASH GENE
Symbol RPN2 contributors: mct/npt - updated : 09-12-2009
HGNC name ribophorin II
HGNC id 10382
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Rpn2
homolog to yeast S.cerevisiae oligosaccharyl transferase subunit SWP1
homolog to Drosophila CG6370
homolog to C.elegans M01A10.3
Homologene
FAMILY
  • ribophorin II family
  • SWP1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text type I membrane protein
    basic FUNCTION
  • catalysing the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor onto asparagine acceptor sites within an Asn-X-Ser/Thr consensus motif in newly synthesized proteins
  • required for substrate translocation and gating of the proteolytic channel (Rosenzweig 2008)
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component with RPN1 and DDOST of N-oligosacccharyl transferase
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ADRM1 (interacts with a base subunit RPN2 via its amino-terminus) (Hamazaki 2006)
    • cell & other
    REGULATION
    Other regulated by S-glutathionylation of the regulatory subunit inhibits 26 S proteasomal function (Zmijewski 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS