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FLASH GENE

Symbol

RPN2

contributors: mct/npt - updated : 09-12-2009

HGNC name	ribophorin II
HGNC id	10382

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	62.57 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001135771 17 - 2490 NP_001129243 - 615 - Zmijewski (2009) NM_002951 17 - 2538 NP_002942 - 631 - Zmijewski (2009)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine pancreas       highly   thyroid       highly Reproductive female system uterus cervix   highly   female system ovary

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Rpn2
	homolog to yeast S.cerevisiae oligosaccharyl transferase subunit SWP1
	homolog to Drosophila CG6370
	homolog to C.elegans M01A10.3

Homologene

FAMILY	ribophorin II family
	SWP1 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	type I membrane protein

basic FUNCTION	catalysing the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor onto asparagine acceptor sites within an Asn-X-Ser/Thr consensus motif in newly synthesized proteins
	required for substrate translocation and gating of the proteolytic channel (Rosenzweig 2008)

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component with RPN1 and DDOST of N-oligosacccharyl transferase

INTERACTION

DNA

RNA

small molecule

protein

interacting with ADRM1 (interacts with a base subunit RPN2 via its amino-terminus) (Hamazaki 2006)

cell & other

REGULATION

Other

regulated by S-glutathionylation of the regulatory subunit inhibits 26 S proteasomal function (Zmijewski 2009)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS