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FLASH GENE
Symbol UGP2 contributors: mct - updated : 20-11-2018
HGNC name UDP-glucose pyrophosphorylase 2
HGNC id 12527
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , hexamer
HOMOLOGY
Homologene
FAMILY eukaryotic UDPGP family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • playing a central role as a glucosyl donor in cellular metabolic pathways
  • is an essential octameric enzyme in nucleotide sugar metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    hypoxia that upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1), two enzymes involved in the biosynthesis of glycogen
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE83
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • positive expression of UGP2 and CFL1 can serve a valuable prognostic factor in pancreatic cancer
  • positive PTPN11 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer
    • Therapy target
    ANIMAL & CELL MODELS