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FLASH GENE

Symbol

UGP2

contributors: mct - updated : 20-11-2018

HGNC name	UDP-glucose pyrophosphorylase 2
HGNC id	12527

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	50.60 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006759 10 - 2185 NP_006750 - 508 - 2012 22132858 NM_001001521 10 - 2129 NP_001001521 - 497 predominantly expressed in brain 2012 22132858

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive esophagus       highly   intestine       highly   liver       highly Homo sapiens Nervous brain       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , hexamer

HOMOLOGY

Homologene

FAMILY

eukaryotic UDPGP family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	playing a central role as a glucosyl donor in cellular metabolic pathways
	is an essential octameric enzyme in nucleotide sugar metabolism

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by	thyroid hormones
	hypoxia that upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1), two enzymes involved in the biosynthesis of glycogen

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE83

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	positive expression of UGP2 and CFL1 can serve a valuable prognostic factor in pancreatic cancer
	positive PTPN11 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer
Therapy target

ANIMAL & CELL MODELS