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FLASH GENE
Symbol UGP2 contributors: mct - updated : 20-11-2018
HGNC name UDP-glucose pyrophosphorylase 2
HGNC id 12527
Corresponding disease
EIEE83 Epileptic encephalopathy, early infantile, 83
Location 2p15      Physical location : 64.068.097 - 64.118.695
Synonym name
  • UTP-glucose 1 phosphate uridyltransferase
  • uridyl diphosphate glucose pyrophosphorylase 2
    • Synonym symbol(s) UGPP2, UDPGP2, UDPG
    EC.number 2.7.7.9
    DNA
    TYPE functioning gene
    STRUCTURE 50.60 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2185 - 508 - 2012 22132858
    10 - 2129 - 497 predominantly expressed in brain 2012 22132858
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     intestine   highly
     liver   highly Homo sapiens
    Nervousbrain   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , hexamer
    HOMOLOGY
    Homologene
    FAMILY eukaryotic UDPGP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing a central role as a glucosyl donor in cellular metabolic pathways
  • is an essential octameric enzyme in nucleotide sugar metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    hypoxia that upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1), two enzymes involved in the biosynthesis of glycogen
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE83
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • positive expression of UGP2 and CFL1 can serve a valuable prognostic factor in pancreatic cancer
  • positive PTPN11 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer
    • Therapy target
    ANIMAL & CELL MODELS