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FLASH GENE

Symbol

TUBA4A

contributors: - updated : 31-08-2007

HGNC name	tubulin, alpha 4a
HGNC id	12407

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to C.elegans tba-2
	ortholog to rattus tuba4 (92 pc)

Homologene

FAMILY

tubulin superfamily composed of six distinct families

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION

major components of microtubules, having a GTPase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer of alpha and beta tubulin

INTERACTION

DNA

RNA

small molecule	nucleotide,
	binds two moles of GTP, one at an
	exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain

protein

GRM7

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS