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FLASH GENE

Symbol

TUBA4A

contributors: - updated : 31-08-2007

HGNC name	tubulin, alpha 4a
HGNC id	12407

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q35      Physical location : 220.115.000 - 220.118.638
Synonym name	testis-specific alpha tubulin
Synonym symbol(s)	FLJ30169, H2-ALPHA, TUBA1

DNA

TYPE	functioning gene
STRUCTURE	3.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two additional related transcripts expressed in every tissue (Dobner)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils       highly Nervous brain       highly Reproductive male system testis     specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to C.elegans tba-2
	ortholog to rattus tuba4 (92 pc)

Homologene

FAMILY

tubulin superfamily composed of six distinct families

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION

major components of microtubules, having a GTPase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer of alpha and beta tubulin

INTERACTION

DNA

RNA

small molecule	nucleotide,
	binds two moles of GTP, one at an
	exchangeable site on the beta chain and one at a nonexchangeable site on the alpha-chain

protein

GRM7

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS