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FLASH GENE
Symbol HMX3 contributors: mct/npt - updated : 11-04-2008
HGNC name H6 family homeobox 3
HGNC id 5019
DNA
TYPE functioning gene
STRUCTURE 1.68 kb     2 Exon(s)
MAPPING cloned N linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1074 - 357 - Miller (2009)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Reproductivefemale systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text expressed in the craniofacial region of developing embryos
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • HMX homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be functioning redundantly to control embryonic development of the central nervous system
  • have a role in sensorineural hearing (Miller 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for human inner ear vestibular development and a role in sensorineural hearing observed in del 10q26 patients (Miller 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    hmx2/hmx3 knockout mice have vestibular anomalies