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FLASH GENE

Symbol

GLE1

contributors: mct/shn - updated : 07-11-2019

HGNC name	GLE1 RNA export mediator homolog (yeast)
HGNC id	4315

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	37.61 kb     16 Exon(s)

regulatory sequence	Promoter
text structure	wild-type GLE1 protomers form discrete multimers and higher-order disk structures in vitro, with evidence for dimer formation happening in living cells

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D9S918 - D9S1827 - GLE1 - D9S290 - D9S260 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001003722 16 splicing 3350 NP_001003722 - 698 has distinct steady-state localization at the nuclear pore complex 2013 24243016 GLE1B NM_001499 14 splicing 2266 NP_001490 - 659 is predominantly cytoplasmic 2013 24243016 GLE1A lacks the C-terminal hCG1-binding domain

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Reproductive male system testis     highly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal 29 AAs responsible for the interaction with NUP155 and for the targeting of GLE1 to the NPC (nuclear pore complex), with a coiled-coil domain )
	a leucine-rich nuclear export sequence essential for poly(A)+RNA export

HOMOLOGY

interspecies	ortholog to Gle1, Mus musculus
	homolog to S.cerevisiae Gle1p
	ortholog to gle1, Danio rerio
	ortholog to Gle1, Rattus norvegicus
	ortholog to GLE1, Pantroglodytes

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
	intracellular,nuclear envelope,pore
text	localized to nuclear pore complexes
	its shuttling between the nucleoplasm and cytoplasm is essential for efficient mRNA export in human cells

basic FUNCTION	may act at a terminal step in the export of mature RNA messages to the cytoplasm
	functions in poly(A)+ RNA export
	critical role of normal mRNA processing in the development and survival of anterior motoneurons
	playing a role with DDX19B in translation termination (Dossani 2009)
	role in translation initiation through regulation of the initiation factor Ded1
	multifunctional protein that regulates gene expression at multiple steps: nuclear mRNA export, translation initiation, and translation termination
	specific requirement for proper GLE1 oligomerization during mRNA export, but not for GLE1 roles in translation
	disruption of specific GLE1 mechanistic steps in export and/or translation results in different pathological outcomes
	is a conserved modulator of RNA-dependent DEAD-box proteins required for mRNA export, translation, and stress responses

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

with NUP155 and NUPL2 formed a heterotrimeric complex (these two nucleoporins were required for the nuclear pore complex localization of GLE1)

INTERACTION

DNA

RNA

small molecule

protein	nuclear pore complex protein Nup155
	nucleoporin hCG1
	eIF3
	inositol hexakisphosphate (IP(6))
	Ded1
	MAPKs and GSK3 phosphorylate GLE1 and thereby coordinate stress granules (SGs) dynamics by altering DDX3X function
	nuclear role for GLE1 in coordinating DDX1 function in transcription termination complexes

cell & other

REGULATION

Other

is regulated by phosphorylation during heat shock stress

ASSOCIATED DISORDERS

corresponding disease(s)

LCCS1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS