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FLASH GENE
Symbol ALG8 contributors: mct/npt - updated : 25-09-2009
HGNC name asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
HGNC id 23161
Corresponding disease
CDG1H congenital disorder of the glycosylation, type 1H
Location 11q14.1      Physical location : 77.811.987 - 77.850.699
Synonym name
  • asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
  • dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase
  • asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
  • Synonym symbol(s) MGC2840, HUSSY-02
    EC.number 2.4.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 38.71 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30 GARP 11q13.5-q14 glycoprotein A repetitions predominant LOC390226 11 similar to Olfactory guanylyl cyclase GC-D precursor (Guanylate cyclase, olfactory) E2IG4 11q13.3 hypothetical protein, estradiol-induced PHCA 11q13.4 phytoceramidase, alkaline IMAGE:4907098 11q13.4 beta-1,3-N-acetylglucosaminyltransferase protein CAPN5 11q14 calpain 5 OMP 11q13 olfactory marker protein MYO7A 11q13.5 myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) LOC220032 11q13.4 GDPD domain containing protein LOC387791 11 similar to Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) PAK1 11q13.5-q14.1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) LOC387792 11 LOC387792 AQP11 11q13.4 aquaporin 11 CLNS1A 11q13.5-q14.1 chloride channel, nucleotide-sensitive, 1A HBXAP 11q13.4-q14.1 hepatitis B virus x associated protein PTD015 11q13.4 PTD015 protein MGC16733 11q13.4 hypothetical gene MGC16733 similar to CG12113 KCTD14 11q13.4 potassium channel tetramerisation domain containing 14 THRSP 11q13.5 thyroid hormone responsive (SPOT14 homolog, rat) NDUFC2 11q12.1-q13.14 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa ALG8 11pter-p15.5 asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase) LOC387793 11 hypothetical gene supported by BC062331 LOC387794 11 similar to ubiquitin specific protease 38; HP43.8KD protein USP35 11q13.4 ubiquitin specific protease 35 GAB2 11q13.4-q13.5 GRB2-associated binding protein 2 FLJ23441 11q13.4 hypothetical protein FLJ23441 ODZ4 11q13.4 odd Oz/ten-m homolog 4 LOC387795 11 LOC387795
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1668 60 526 - Otsuki, Schollen (2004)
    the shortest transcript, but encodes the longest isoform
    14 - 1743 - 467 - Otsuki, Schollen (2004)
    contains an additional segment in the coding region
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellumcerebellar cortex 
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines B cells (Ramos cell lines)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine transmembrane domains
  • an ER membrane domain
  • HOMOLOGY
    interspecies ortholog to murine Alg8
    Homologene
    FAMILY
  • Alg6/Alg8 glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • glycosyltransferase (adds the second glucose to the lipid-linked oligosaccharide precursor used in the N-glycosylation of protein)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1H
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS