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FLASH GENE
Symbol TPO contributors: mct/ - updated : 28-03-2012
HGNC name thyroid peroxidase
HGNC id 12015
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one short consensus repeat, sushi structure (see F13B, SRCP1)
    • HOMOLOGY
    Homologene
    FAMILY
  • peroxidase family
  • XPO subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • with DUOX, are present at the apical membrane of thyrocytes
    • basic FUNCTION
  • thyroid peroxidase, thyroid hormone synthesis (iodide organification), and metabolism pathway
  • key enzyme in thyroid hormone production and a universal autoantigen in Graves' and other autoimmune thyroid diseases
  • at the apical membrane of thyrocytes, catalyzes thyroid hormone biosynthesis in the presence of H2O2 produced by DUOX1 and DUOX2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 calcium ion per heterodimer
  • binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer
    • protein
  • interacts with DUOX1, DUOX2 and CYBA
  • binding MPL and NUDC
  • TPO presents a catalase-like effect that protects DUOX1 and DUOX2 from inhibition by H2O2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TIOD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in thyroid carcinoma and its presence may indicate favorable prognosis of papillary cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS