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FLASH GENE
Symbol TPO contributors: mct/ - updated : 28-03-2012
HGNC name thyroid peroxidase
HGNC id 12015
DNA
TYPE functioning gene
STRUCTURE 129.27 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3152 103 933 - 2006 16682284
16 - 2981 - 876 - 2006 16682284
15 - 2930 - 889 - 2006 16682284
15 - 2543 - 760 - 2006 16682284
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly Homo sapiens
Nervousbrain    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrinethyroid cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one short consensus repeat, sushi structure (see F13B, SRCP1)
    • HOMOLOGY
    Homologene
    FAMILY
  • peroxidase family
  • XPO subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • with DUOX, are present at the apical membrane of thyrocytes
    • basic FUNCTION
  • thyroid peroxidase, thyroid hormone synthesis (iodide organification), and metabolism pathway
  • key enzyme in thyroid hormone production and a universal autoantigen in Graves' and other autoimmune thyroid diseases
  • at the apical membrane of thyrocytes, catalyzes thyroid hormone biosynthesis in the presence of H2O2 produced by DUOX1 and DUOX2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 calcium ion per heterodimer
  • binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer
    • protein
  • interacts with DUOX1, DUOX2 and CYBA
  • binding MPL and NUDC
  • TPO presents a catalase-like effect that protects DUOX1 and DUOX2 from inhibition by H2O2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TIOD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in thyroid carcinoma and its presence may indicate favorable prognosis of papillary cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS