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FLASH GENE
Symbol TPO contributors: mct/ - updated : 28-03-2012
HGNC name thyroid peroxidase
HGNC id 12015
Corresponding disease
TIOD total iodide organification defect
Location 2p25.3      Physical location : 1.417.232 - 1.546.498
Synonym name
  • thyroid microsomal antigen
  • thyroperoxidase
    • Synonym symbol(s) TPX, MSA, TDH2A
    EC.number 1.11.1.8
    DNA
    TYPE functioning gene
    STRUCTURE 129.27 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3152 103 933 - 2006 16682284
    16 - 2981 - 876 - 2006 16682284
    15 - 2930 - 889 - 2006 16682284
    15 - 2543 - 760 - 2006 16682284
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly Homo sapiens
    Nervousbrain    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrinethyroid cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one short consensus repeat, sushi structure (see F13B, SRCP1)
    • HOMOLOGY
    Homologene
    FAMILY
  • peroxidase family
  • XPO subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • with DUOX, are present at the apical membrane of thyrocytes
    • basic FUNCTION
  • thyroid peroxidase, thyroid hormone synthesis (iodide organification), and metabolism pathway
  • key enzyme in thyroid hormone production and a universal autoantigen in Graves' and other autoimmune thyroid diseases
  • at the apical membrane of thyrocytes, catalyzes thyroid hormone biosynthesis in the presence of H2O2 produced by DUOX1 and DUOX2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 calcium ion per heterodimer
  • binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer
    • protein
  • interacts with DUOX1, DUOX2 and CYBA
  • binding MPL and NUDC
  • TPO presents a catalase-like effect that protects DUOX1 and DUOX2 from inhibition by H2O2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TIOD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in thyroid carcinoma and its presence may indicate favorable prognosis of papillary cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS