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FLASH GENE

Symbol

DPPA3

contributors: mct - updated : 13-07-2017

HGNC name	developmental pluripotency associated 3
HGNC id	19199

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         loss of maternal DPPA3 results in widespread transcriptional mis-regulation and a partial failure of maternal-to-zygotic transition (MZT) tumoral     --over   enhanced the metastatic ability of B16 melanoma cells, presumably through the induction of metastasis-related genes constitutional       loss of function led to developmental arrest at the preimplantation stage, accompanied by frequent chromosome segregation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Stella-null embryos exhibited impaired CF and reduced expression of the reverse strand of major satellite repeats