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FLASH GENE

Symbol

THRB

contributors: mct/ - updated : 12-06-2015

HGNC name	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
HGNC id	11799

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

GHTR , THRB

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulated in breast cancer tumoral     --low   in follicular thyroid cancer tumoral     --low   hypermethylation of THRB as an alternative gene silencing mechanism is highly prevalent in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual   inhibition of THRA, THRB locally in the retina is a therapeutic strategy for retinal degeneration

ANIMAL & CELL MODELS

mice with a targeted mutation exhibit impaired growth and resistance to THR