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FLASH GENE
Symbol RAD9B contributors: mct - updated : 28-01-2009
HGNC name RAD9 homolog B (S. pombe)
HGNC id 21700
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal PCNA-like domain
    • HOMOLOGY
    interspecies homolog to murine Rad9
    intraspecies paralog to RAD9A
    Homologene
    FAMILY
  • rad9 family
    • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • can serve as a biomarker in particular for testicular seminomas and might be causally related to the disease
  • RAD9A, RAD9B plays a role in locating Claspin to sites of DNA damage, facilitating its role during the CHEK1-mediated checkpoint response
  • migrates to nucleoli after nucleolar stress in an ATR- and JNK-dependent manner, in a newly described nucleolar domain structure containing CDKN1A
  • relationship between RAD9B and pathways for checkpoints, stress response and nucleolar function
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with RAD1, RAD9A, HUS1, HUS1B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with RAD1, RAD9, HUS1, HUS1B
  • associates with HUS1, RAD1, and RAD17, suggesting that it is a RAD9 paralog that engages in similar biochemical reactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in seminomas, relative to normal testis control, nonseminomas, or Leydig tumor cells
    constitutional     --over  
    overexpression of RAD9B delays cells in G1 phase 20305300
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS