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FLASH GENE
Symbol RAD9B contributors: mct - updated : 28-01-2009
HGNC name RAD9 homolog B (S. pombe)
HGNC id 21700
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal PCNA-like domain
    • HOMOLOGY
    interspecies homolog to murine Rad9
    intraspecies paralog to RAD9A
    Homologene
    FAMILY
  • rad9 family
    • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • can serve as a biomarker in particular for testicular seminomas and might be causally related to the disease
  • RAD9A, RAD9B plays a role in locating Claspin to sites of DNA damage, facilitating its role during the CHEK1-mediated checkpoint response
  • migrates to nucleoli after nucleolar stress in an ATR- and JNK-dependent manner, in a newly described nucleolar domain structure containing CDKN1A
  • relationship between RAD9B and pathways for checkpoints, stress response and nucleolar function
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with RAD1, RAD9A, HUS1, HUS1B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with RAD1, RAD9, HUS1, HUS1B
  • associates with HUS1, RAD1, and RAD17, suggesting that it is a RAD9 paralog that engages in similar biochemical reactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in seminomas, relative to normal testis control, nonseminomas, or Leydig tumor cells
    constitutional     --over  
    overexpression of RAD9B delays cells in G1 phase 20305300
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS