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FLASH GENE

Symbol

RAD9B

contributors: mct - updated : 28-01-2009

HGNC name	RAD9 homolog B (S. pombe)
HGNC id	21700

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	29.89 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152442 12 - 1898 NP_689655 - 429 - 2003 14611806

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   lowly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N terminal PCNA-like domain

HOMOLOGY

interspecies

homolog to murine Rad9

intraspecies

paralog to RAD9A

Homologene

FAMILY

rad9 family

CATEGORY

regulatory , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	can serve as a biomarker in particular for testicular seminomas and might be causally related to the disease
	RAD9A, RAD9B plays a role in locating Claspin to sites of DNA damage, facilitating its role during the CHEK1-mediated checkpoint response
	migrates to nucleoli after nucleolar stress in an ATR- and JNK-dependent manner, in a newly described nucleolar domain structure containing CDKN1A
	relationship between RAD9B and pathways for checkpoints, stress response and nucleolar function

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

with RAD1, RAD9A, HUS1, HUS1B

INTERACTION

DNA

RNA

small molecule

protein	with RAD1, RAD9, HUS1, HUS1B
	associates with HUS1, RAD1, and RAD17, suggesting that it is a RAD9 paralog that engages in similar biochemical reactions

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in seminomas, relative to normal testis control, nonseminomas, or Leydig tumor cells constitutional     --over   overexpression of RAD9B delays cells in G1 phase 20305300

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS