SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,nucleus,nucleoplasm
|
text
| on intracellular membranes, including the endoplasmic reticulum |
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resident endoplasmic reticulum (ER) protein that is involved in controlling the release of zinc from this organelle into the cytosol |
basic FUNCTION
| would be involved in heavy metal ion transport |
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involved in the control of intracellular zinc homeostasis |
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functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell |
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releases zinc from endoplasmic reticulum and might be required for tyrosine kinase activation (Hogstrand 2009) |
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importance of ZIP7 in maintenance of intestinal epithelial homeostasis through the regulation of ER function in proliferative progenitor cells and maintenance of intestinal stem cells |
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likely ER-localized SLC39A7 can potentially sequester zinc to these histidine-rich regions and therefore provides a mechanism that is protective of this cellular structure |
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SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis |