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FLASH GENE

Symbol

SLC39A7

contributors: mct - updated : 12-11-2021

HGNC name	solute carrier family 39 (zinc transporter), member 7
HGNC id	4927

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	AGM9 agammaglobulinemia 9, autosomal recessive
Location	6p21.32      Physical location : 4.400.825 - 33.172.213
Synonym name	HLA class II region expressed gene KE4
	Ke4 gene, mouse, human homolog of
	histidine-rich membrane protein Ke4
	really interesting new gene 5 protein
	zrt-, Irt-like protein 7
Synonym symbol(s)	KE4, HKE4, RING5, H2-KE4, D6S115E, D6S2244E, ZIP7, AGM9

DNA

TYPE	functioning gene
STRUCTURE	3.60 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001288777 8 - 1826 NP_001275706 - 344 - Kim NM_006979 7 - 2413 NM_006979 49.9 469 - Kim NM_001077516 8 - 2110 NP_001070984 - 469 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive esophagus       highly   stomach       highly Lymphoid/Immune lymph node         Nervous nerve spinal nerve sciatic   highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

histidine-rich charge clusters

HOMOLOGY

interspecies

homolog to murine Ke4

Homologene

FAMILY	ZIP transporter (tc 2.a.5) family
	KE4/catsup subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,nucleoplasm
text	on intracellular membranes, including the endoplasmic reticulum
	resident endoplasmic reticulum (ER) protein that is involved in controlling the release of zinc from this organelle into the cytosol

basic FUNCTION	would be involved in heavy metal ion transport
	involved in the control of intracellular zinc homeostasis
	functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell
	releases zinc from endoplasmic reticulum and might be required for tyrosine kinase activation (Hogstrand 2009)
	importance of ZIP7 in maintenance of intestinal epithelial homeostasis through the regulation of ER function in proliferative progenitor cells and maintenance of intestinal stem cells
	likely ER-localized SLC39A7 can potentially sequester zinc to these histidine-rich regions and therefore provides a mechanism that is protective of this cellular structure
	SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	heavy metal ion transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

activation of SLC39A7 by CNSK2A1, a kinase that is antiapoptotic and promotes cell division, suggesting that SLC39A7 may provide a target for anticancer drug development

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AGM9

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function resulted in augmented ER stress and impaired receptor trafficking, thereby globally affecting downstream signaling

Susceptibility

Variant & Polymorphism

Candidate gene	might be a novel target for diseases such as cancer where prevention of tyrosine kinase activation would be therapeutically advantageous (Hogstrand 2009)
Marker
Therapy target

ANIMAL & CELL MODELS