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FLASH GENE
Symbol SLC30A8 contributors: /mct - updated : 14-04-2006
HGNC name solute carrier family 30 (zinc transporter), member 8
HGNC id 20303
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • a histidine-rich loop between transmembrane domains IV and V
    • HOMOLOGY
    Homologene
    FAMILY
  • cation diffusion facilitator (CDF) transporter family
  • SLC30A subfamily
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text in synaptic vesicles and in secretion vesicles membrane
    basic FUNCTION
  • involved in accumulation of zinc in synaptic vesicles
  • facilitating the accumulation of zinc from the cytoplasm into intracellular insulin-containing vesicles
  • involved in insulin maturation, storage and secretion (Cauchi 2010)
  • role in pancreatic islets (is particularly required for the normal accumulation of zinc in beta-cell granules) (Cauchi 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes
    Variant & Polymorphism other
  • SLC30A8 rs13266634 polymorphism is among the most replicated genetic markers of T2D in Europeans and East Asian (Cauchi 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS