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FLASH GENE
Symbol SLC25A22 contributors: mct/npt - updated : 18-12-2009
HGNC name solute carrier family 25 (mitochondrial carrier: glutamate), member 22
HGNC id 19954
Corresponding disease
EIEE3 epileptic encephalopathy, early infantile, 3
Location 11p15.5      Physical location : 790.475 - 798.269
Synonym name
  • mitochondrial glutamate carrier 1
  • glutamate/H(+) symporter 1
  • Synonym symbol(s) GC1, FLJ13044, NET44
    DNA
    TYPE functioning gene
    STRUCTURE 5.75 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2780 - 323 - Molinari (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrainforebrain   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Nervousastrocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four EF-hand calcium-binding domains
  • three solcar repeats
  • HOMOLOGY
    interspecies ortholog to murine Slc25a22
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in the transport of glutamate across the inner mitochondrial membrane, glutamate is cotransported with H(+)
  • may be having a function in the urea cycle
  • catalyze the transport of glutamate across the inner mitochondrial membrane, either by proton co-transport or in exchange for hydroxyl ions (Casimir 2009)
  • having a role in control of insulin secretion upon elevated glucose stimulation (Casimir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text L-glutamate
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Slc25a22
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION calcium-dependent mitochondrial aspartate and glutamate carrier. may be having a function in the urea cycle.
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS