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FLASH GENE
Symbol SLCO5A1 contributors: mct - updated : 03-10-2019
HGNC name solute carrier organic anion transporter family, member 5A1
HGNC id 19046
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
Nervousbrain   highly
Reproductivefemale systemuterus   
 female systembreastmammary gland   Homo sapiens
Respiratoryrespiratory tractlarynx   
Urinarybladder    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly expressed in fetal brain and heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 transmembrane domains
    • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier organic anion transporter superfamily
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • SLCO5A1 and SLCO3A1 localized to the plasma membrane of epithelial cells of the lactiferous ducts in normal breast tissue
    • basic FUNCTION
  • mediating the Na(+)-independent transport of organic anions
  • might be a non-classical OATP family member which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL8q13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be novel biomarker for tumor progression and the development of metastasis in small cell lung cancer (SCLC) patients
    • Therapy target
    ANIMAL & CELL MODELS