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FLASH GENE

Symbol

SLCO5A1

contributors: mct - updated : 03-10-2019

HGNC name	solute carrier organic anion transporter family, member 5A1
HGNC id	19046

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DEL8q13 chromosome 8q13 microdeletion
Location	8q13.3      Physical location : 70.584.569 - 70.747.299
Synonym name	organic anion transporter polypeptide-related protein 4
	solute carrier family 21 (organic anion transporter), member 15
	solute carrier family 21 member 15
Synonym symbol(s)	OATP-J, OATPRP4, SLC21A15, OATP5A1, FLJ39560

DNA

TYPE	functioning gene
STRUCTURE	162.63 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030958 10 - 3806 NP_112220 91.9 848 - 2003 12507753 NM_001146009 9 - 3430 NP_001139481 85.8 793 - 2003 12507753 NM_001146008 8 - 3751 NP_001139480 73.8 687 - 2003 12507753

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   highly Nervous brain       highly Reproductive female system uterus         female system breast mammary gland     Homo sapiens Respiratory respiratory tract larynx       Urinary bladder

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune dendritic cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	highly expressed in fetal brain and heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

12 transmembrane domains

HOMOLOGY

Homologene

FAMILY

solute carrier organic anion transporter superfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	SLCO5A1 and SLCO3A1 localized to the plasma membrane of epithelial cells of the lactiferous ducts in normal breast tissue

basic FUNCTION	mediating the Na(+)-independent transport of organic anions
	might be a non-classical OATP family member which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL8q13

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	might be novel biomarker for tumor progression and the development of metastasis in small cell lung cancer (SCLC) patients
Therapy target

ANIMAL & CELL MODELS