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| Nact (also known as Slc13a5)-knockout mice have been found to have increased hepatic mitochondrial biogenesis, higher lipid oxidation and energy expenditure, and reduced lipogenesis, which taken together protect the mice from obesity and insulin resistance  | |
mIndy was induced in livers of fasted as well as in high-fat-diet-streptozotocin diabetic rats, in which Creb is constitutively activated. mIndy induction was completely prevented when Creb was depleted in these rats by antisense oligonucleotides |