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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

SLC13A5

contributors: mct - updated : 28-02-2014

HGNC name	solute carrier family 13 (sodium-dependent citrate transporter), member 5
HGNC id	23089

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE25

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   might be a therapeutic target for the treatment of obesity and type 2 diabetes obesity     might be a therapeutic target for the treatment of obesity and type 2 diabetes

ANIMAL & CELL MODELS

	Nact (also known as Slc13a5)-knockout mice have been found to have increased hepatic mitochondrial biogenesis, higher lipid oxidation and energy expenditure, and reduced lipogenesis, which taken together protect the mice from obesity and insulin resistance
	mIndy was induced in livers of fasted as well as in high-fat-diet-streptozotocin diabetic rats, in which Creb is constitutively activated. mIndy induction was completely prevented when Creb was depleted in these rats by antisense oligonucleotides