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FLASH GENE
Symbol SLC13A5 contributors: mct - updated : 28-02-2014
HGNC name solute carrier family 13 (sodium-dependent citrate transporter), member 5
HGNC id 23089
Corresponding disease
EIEE25 early-onset epileptic encephalopathy-25
Location 17p13.1      Physical location : 6.588.040 - 6.616.740
Synonym name
  • sodium-coupled citrate transporter
  • solute carrier family 13 member 5
  • Synonym symbol(s) NACT, MGC138356, mindy
    DNA
    TYPE functioning gene
    STRUCTURE 28.71 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • CREB-binding site within thepromoter
  • MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0523 17p13.2 KIAA0523 protein AIPL1 17p13.1 aryl hydrocarbon receptor interacting protein-like 1 FLJ10156 17p13.2 hypothetical protein FLJ10156 PITPNM3 17p13 PITPNM family member 3 KIAA0753 17p13.2 PITPNM family member 3 MGC14353 CGI-125 17p13.2 CGI-125 protein LOC388327 17 hypothetical gene supported by BC052606 LOC342531 17p13.2 similar to Arachidonate 15-lipoxygenase (Arachidonate omega-6 lipoxygenase) (15-LOX) SLC13A5 17p13.2 solute carrier family 13 (sodium-dependent citrate transporter), member 5 HSXIAPAF1 17p13.2 XIAP associated factor-1 MGC35179 17p13.2 hypothetical protein MGC35179 TEKT1 17p13.2 tektin 1 ALOX12P2 17p13.1 arachidonate 12-lipoxygenase pseudogene 2 ALOX12 17p13.1 arachidonate 12-lipoxygenase LOC388328 17 LOC388328 MGC49942 17p13.2 hypothetical protein MGC49942 BCL6B 17p13.1 B-cell CLL/lymphoma 6, member B (zinc finger protein) LOC201232 SLC16A11 17p13.2 solute carrier family 16 (monocarboxylic acid transporters), member 11 CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 ASGR2 17p13.1 asialoglycoprotein receptor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3187 - 525 - 2002 12177002
    12 - - - - - 2002 12177002
    11 - 3178 - 522 - 2002 12177002
    12 - 3316 - 568 - 2002 12177002
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrainforebraincerebral cortex   Mus musculus
     brain     Homo sapiens
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    Nervousneuron Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 11 transmembrane domains
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    intraspecies homolog to SLC13A2,SLC13A3
    Homologene
    FAMILY
  • SLC13A transporter family
  • NADC subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in the cellular utilization of citrate in blood for the synthesis of fatty acids and cholesterol (liver) and for the generation of energy (liver and brain)
  • may be facilitating the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol
  • tricarboxylate plasma transporter with a preference for citrate
  • primarily a citrate transporter located in the liver and brain, and its activity may regulate metabolic processes
  • CREB-dependent glucagon target gene that is induced in fasting and in type 2 diabetes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE25
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    might be a therapeutic target for the treatment of obesity and type 2 diabetes
    obesity  
    might be a therapeutic target for the treatment of obesity and type 2 diabetes
    ANIMAL & CELL MODELS
  • Nact (also known as Slc13a5)-knockout mice have been found to have increased hepatic mitochondrial biogenesis, higher lipid oxidation and energy expenditure, and reduced lipogenesis, which taken together protect the mice from obesity and insulin resistance
  • mIndy was induced in livers of fasted as well as in high-fat-diet-streptozotocin diabetic rats, in which Creb is constitutively activated. mIndy induction was completely prevented when Creb was depleted in these rats by antisense oligonucleotides