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FLASH GENE

Symbol

SLC12A9

contributors: mct/npt - updated : 06-10-2009

HGNC name	solute carrier family 12 (potassium/chloride transporters), member 9
HGNC id	17435

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	12-transmembrane domain (TM) region,
	two N-linked glycosylation sites between TM(5) and TM(6), and
	a large intracellular loop at the C-terminus containing protein kinase C phosphorylation sites (Wenz 2009)

HOMOLOGY

interspecies

homolog to C .elegans k02a2.3.

Homologene

FAMILY

SLC12A transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

may be modulating cation-chloride cotransporter (CCC)activity or kinetics through heterodimer formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

potent activator of SLC12A5 (activates SLC12A5 by heteromer formation)(Wenz 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS