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FLASH GENE

Symbol

SLC10A4

contributors: mct - updated : 08-10-2018

HGNC name	solute carrier family 10 (sodium/bile acid cotransporter family), member 4
HGNC id	22980

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         results in neurotransmitter imbalance and cognitive impairment constitutional     --low   associated with increase in the severity of AD-related neuronal degeneration

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   may represent a novel target for treatment of disorders affecting motor neurons

ANIMAL & CELL MODELS

loss of Slc10a4 in mice resulted in reduced striatal serotonin, noradrenaline, and dopamine concentrations and a significantly higher dopamine turnover ratio