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FLASH GENE
Symbol SLC10A4 contributors: mct - updated : 08-10-2018
HGNC name solute carrier family 10 (sodium/bile acid cotransporter family), member 4
HGNC id 22980
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular N-terminus of SLC10A4 was predicted to be relatively longer at the amino acid level than those of SLC10A1, SLC10A2 and SLC10A6
    • HOMOLOGY
    Homologene
    FAMILY sodium/bile acid symporter family (SBF).
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • SLC10A4 localized at the plasma membrane and in intracellular vesicles and showed considerable co-localization with SLC10A1
  • synaptic vesicle protein
    • basic FUNCTION
  • having bile acid/sodium symporter activity.
  • exhibiting broad substrate specificity & transports various nonbile acid organic compounds as well
  • may participate in vesicular storage or exocytosis of neurotransmitters or mastocyte mediators
  • has no transport activity for bile acids
  • SLC10A4 appears to be a protease-activated transporter and transports bile acids
  • is a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation
  • have a modulatory role in central cholinergic signalling
  • regulatory role for the presynaptic vesicle protein SLC10A4 in neuromuscular junction (NMJ) development and function
  • modulates likely NMJ transmission efficiency
  • modifies mast cell degranulation
  • acts as a regulator of degranulation in vitro and of mast cell-related reactions in vivo
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC10A1 co-localizes and associates with SLC10A4 and SLC10A6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    results in neurotransmitter imbalance and cognitive impairment
    constitutional     --low  
    associated with increase in the severity of AD-related neuronal degeneration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    may represent a novel target for treatment of disorders affecting motor neurons
    ANIMAL & CELL MODELS
  • loss of Slc10a4 in mice resulted in reduced striatal serotonin, noradrenaline, and dopamine concentrations and a significantly higher dopamine turnover ratio