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FLASH GENE

Symbol

SLC10A4

contributors: mct - updated : 08-10-2018

HGNC name	solute carrier family 10 (sodium/bile acid cotransporter family), member 4
HGNC id	22980

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152679 3 - 2118 NP_689892 - 437 - 2013 23589386

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain midbrain     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Nervous cholinergic neuron Rattus norvegicus Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

extracellular N-terminus of SLC10A4 was predicted to be relatively longer at the amino acid level than those of SLC10A1, SLC10A2 and SLC10A6

HOMOLOGY

Homologene

FAMILY

sodium/bile acid symporter family (SBF).

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	SLC10A4 localized at the plasma membrane and in intracellular vesicles and showed considerable co-localization with SLC10A1
	synaptic vesicle protein

basic FUNCTION	having bile acid/sodium symporter activity.
	exhibiting broad substrate specificity & transports various nonbile acid organic compounds as well
	may participate in vesicular storage or exocytosis of neurotransmitters or mastocyte mediators
	has no transport activity for bile acids
	SLC10A4 appears to be a protease-activated transporter and transports bile acids
	is a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation
	have a modulatory role in central cholinergic signalling
	regulatory role for the presynaptic vesicle protein SLC10A4 in neuromuscular junction (NMJ) development and function
	modulates likely NMJ transmission efficiency
	modifies mast cell degranulation
	acts as a regulator of degranulation in vitro and of mast cell-related reactions in vivo

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

SLC10A1 co-localizes and associates with SLC10A4 and SLC10A6

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         results in neurotransmitter imbalance and cognitive impairment constitutional     --low   associated with increase in the severity of AD-related neuronal degeneration

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   may represent a novel target for treatment of disorders affecting motor neurons

ANIMAL & CELL MODELS

loss of Slc10a4 in mice resulted in reduced striatal serotonin, noradrenaline, and dopamine concentrations and a significantly higher dopamine turnover ratio