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FLASH GENE
Symbol SLC10A4 contributors: mct - updated : 08-10-2018
HGNC name solute carrier family 10 (sodium/bile acid cotransporter family), member 4
HGNC id 22980
DNA
TYPE functioning gene
STRUCTURE 6.18 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2118 - 437 - 2013 23589386
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrain  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouscholinergic neuron Rattus norvegicus
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular N-terminus of SLC10A4 was predicted to be relatively longer at the amino acid level than those of SLC10A1, SLC10A2 and SLC10A6
    • HOMOLOGY
    Homologene
    FAMILY sodium/bile acid symporter family (SBF).
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • SLC10A4 localized at the plasma membrane and in intracellular vesicles and showed considerable co-localization with SLC10A1
  • synaptic vesicle protein
    • basic FUNCTION
  • having bile acid/sodium symporter activity.
  • exhibiting broad substrate specificity & transports various nonbile acid organic compounds as well
  • may participate in vesicular storage or exocytosis of neurotransmitters or mastocyte mediators
  • has no transport activity for bile acids
  • SLC10A4 appears to be a protease-activated transporter and transports bile acids
  • is a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation
  • have a modulatory role in central cholinergic signalling
  • regulatory role for the presynaptic vesicle protein SLC10A4 in neuromuscular junction (NMJ) development and function
  • modulates likely NMJ transmission efficiency
  • modifies mast cell degranulation
  • acts as a regulator of degranulation in vitro and of mast cell-related reactions in vivo
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC10A1 co-localizes and associates with SLC10A4 and SLC10A6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    results in neurotransmitter imbalance and cognitive impairment
    constitutional     --low  
    associated with increase in the severity of AD-related neuronal degeneration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    may represent a novel target for treatment of disorders affecting motor neurons
    ANIMAL & CELL MODELS
  • loss of Slc10a4 in mice resulted in reduced striatal serotonin, noradrenaline, and dopamine concentrations and a significantly higher dopamine turnover ratio